Reflections from the GRS and GRC on Cellular and Molecular Mechanisms of Toxicity 2025
The Gordon Research Seminar (GRS) and the Gordon Research Conference (GRC) on Cellular and Molecular Mechanisms of Toxicity were held at the Proctor Academy in Andover, New Hampshire. The seminar and the conference were hosted back-to-back from the 9th until the 15th of August and created a unique opportunity: the GRS provided a platform for graduate students and postdocs to gain confidence and build networks, while the GRC expanded the dialogue across academia, industry, and government with cutting-edge talks and a collaborative spirit. The MicroOrganoLab contributed in two ways, with a keynote speech by Peter Loskill and a poster by Teresa Brandtner. The latter won an award and was recognized as an outstanding poster presented by a graduate student. Teresa also led a discussion session at the GRS, which served as an inspiring learning experience. We are thrilled to announce that Peter Loskill was elected to co-chair the GRC in 2027 followed by chairing the conference in 2029.
Empowering Early-Career Researchers Builds Strong Connections
The GRS played an important role in setting the stage for the main conference. By giving young researchers the opportunity to get to know each other in advance, it created a safe environment to practice poster sessions and talks and to exchange ideas. This experience ensured that early-career participants entered the GRC with confidence and a social network already in place. The supportive environment highlighted how intentional structures can help build connections and foster collaboration among the next generation of toxicologists.
Interdisciplinary and Translational Perspectives Enrich Toxicology
One of the highlights of the GRC program was its diversity in both topics and participants. The sessions covered topics such as Drug-Induced Liver Injury (DILI), genomic modification, xenobiotic-induced immunomodulation, and complex in vitro models, including microphysiological systems. Furthermore, advances and potential applications of AI tools, machine learning, and the toxicological impacts of climate change were highlighted. Importantly, the organizers invited speakers who were not traditional toxicologists, bringing in new methodologies and ideas from other disciplines. Equally valuable was the participation of industry scientists, who added a translational perspective. Lastly, the importance of implementing new approach methods (NAMs), including microphysiological systems, has been emphasized repeatedly and was the focus of several talks.
Diversity and Openness Are Essential for Future Progress
A recurring theme was the importance of considering individual variability in toxicology. Talks repeatedly emphasized that sex and racial differences must be given greater attention in experimental design, data interpretation, and risk assessment. Embracing inclusivity is crucial for achieving improved predictive outcomes and greater equity. The open and relaxed culture of the GRC provided a unique experience and further reinforced this message: with free afternoons, participants could discuss ideas without hierarchy or judgment while hiking or enjoying the lake, which created an atmosphere where all voices could be heard and valued.
In Summary
The GRS and GRC on Cellular and Molecular Mechanisms of Toxicity 2025 stood out for combining novel scientific perspectives with a strong sense of community. From empowering early-career researchers, to integrating interdisciplinary and industry viewpoints, to promoting diversity and openness, the sessions showcased how the future of toxicology can be both more innovative and more inclusive. Beyond the science, New Hampshire offered beautiful natural landscapes, perfect for hiking and enjoying in good company.
We return with fresh ideas, valuable contacts, and renewed motivation to apply these lessons in our own research. We look forward to returning to the GRS and GRC in 2027!
