On 9th of October, Alessia Moruzzi successfully defended her doctoral dissertation with the title „Development of Non-Invasive Technologies for Investigating Cardiac Tissue in a Novel Heart-on-Chip Platform„
During her PhD, she has developed the heart-on-chip. She worked with spheroids derived from induced pluripotent stem cell cardiomyocytes. These spheroids are loaded into the heart-chip via hydrostatic flow into dogbone-shaped chambers, where they fuse to create aligned, contracting cardiac muscle fibers. The system incorporates electrical stimulation through fluidic media connectors acting as electrodes. Additionally, the integration of optical O2 sensor spots into the microfluidic device allows for real-time monitoring of oxygen levels.
The µOrganoLab congratulates Alessia and wishes her all the best in her future endeavors! Way to go Dr. Moruzzi!
