EMBO Workshop in Barcelona

During the conference, Şeyma presented a poster entitled “A Robust Strategy for Integrating Decellularized Human Amniotic Membrane into Microfluidic Organ-on-Chip Platforms.” The work introduces a versatile approach for incorporating decellularized human amniotic membrane into organ-on-chip systems as a biologically active, native extracellular matrix (ECM) barrier. By preserving the structural and biochemical complexity of human tissue-derived ECM, this strategy enables more physiologically relevant cell–matrix interactions and tissue-specific signaling compared to conventional synthetic membranes. Beyond its successful application in both placenta- and retina-on-chip models, the approach establishes a broadly applicable framework for integrating native ECM components into microfluidic platforms, supporting the development of more predictive disease models and next-generation Organ-on-Chip technologies.

A recurring message throughout the workshop was the importance of selecting experimental models that are appropriate for the specific biological question being addressed. While many presentations focused on advances in endothelial cell biology and vascular network formation, there was a strong emphasis on studying Cell–ECM interactions. In particular, participants highlighted the necessity of developing more physiologically relevant microenvironments that better recapitulate the tissue-specific context of human disease. Such approaches are increasingly recognized as essential for unraveling disease mechanisms, capturing complex cellular crosstalk, and improving the translational relevance of in vitro models. Thereby, the Organ-on-Chip technology, as New Approach Methodology (NAM), stood out with the possibility to mimic spatiotemporal influences changing endothelial cell identity, differentiation, and metabolic state. In addition, it enables a flow profile similar to human blood vessels, that contributes to the endothelial alignment and sprouting, making it possible to study barrier formation or neovascularization in vitro.

We are delighted to have been part of this enlightening workshop and gained valuable new insights into the fundamental and translational challenges of today’s vascular research community. With this in mind, we are motivated to find sophisticated solutions to better understand individual disease progression and vascular-dependent therapeutic delivery and success. Our take home message again is that scientific exchange across disciplines remains essential for accelerating the transfer of advanced vascular model systems into future applications.