Why do we need multi-organ models? Multi-organ systems aim to improve the current standards for in vitro and in vivo modeling. This is a more systemic approach to the in vitro study of human (patho-)physiology for drug development and personalized medicine. A large challenge within this field lies in the connection and integration of multiple organ systems within one platform with systemic circulation. ΜOrganoLab PhD candidate, Hannah Graf, has tackled this issue and developed a ‚Plug and Play‘ Multi-Organ System for interconnecting multiple organ-chips.
With the novel µGasket technology, multiple individual organ-chips can be easily connected to a multi-organ platform with systemic circulation without external connectors or additional dead volume. This innovative system consists of a connection platform with integrated µGaskets made of thermoplastic elastomer (TPE) that facilitate for the simple and robust connection of different customizable tissue models with ISO-standard port locations. The plug and play nature of this design enables the use of already established organ models. Each tissue model can be individually treated and cultivated before connecting it into a multi-organ system.
The µGasket system is a user-friendly connection platform that opens the door for creating complex multi-organ models!
Read the full paper here!
