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The field of non-clinical models urgently requires a push towards more physiologically accurate recapitulations of drug interactions and disease progression in the body. This review discusses multi-organ-chips (MOCs), a technology well-suited to provide a species-specific platform to study the various types of metabolism (glucose, lipid, protein, drug) by recreating organ-level function and interaction. For scientists aiming to study human metabolism, this review addresses the technical aspects of MOC development and provides guidelines for correlation to in silico models. Predictive MOCs could enable a reduced dependence on animal models and open doors for economical non-clinical testing and understanding of disease mechanisms.