The ORCHID (Organ-on-Chip development) project started on October 1st, 2017 and was born since the need for a higher awareness level in Europe and in the world towards the science of Organ-on-a-Chip was deeply felt by the main European institutions involved in this field. Its main purpose is to create a roadmap for Organ-on-a-Chip technology and a framework for a potential network of stakeholders. The ORCHID consortium is composed of six European institution, each of which has a determined task and mission within the project. All participants are highly experienced in the Organ-on-a-Chip field and will collaborate with each other to involve several kinds of institution in order to accelerate the process of making this innovative technology an every-day reality which will not be merely confined in research labs. The main duty of the Loskill-Lab will be to assess the economic and social impact of Organ-on-a-Chip technology, concerning both the principle of reduction, refinement and replacement of animal experiments, and the identification of skills needed to form young scientist for the future application of this technology.
Funding: EU-H2020;
Publications
J. Rogal*, K. Schlünder*, P. Loskill
Developer’s Guide to an Organ-on-Chip Model
ACS Biomater. Sci. Eng., 2022, 8, 4643-4647, https://doi.org/10.1021/acsbiomaterials.1c01536
A. Moruzzi, T. Shroff, S. Keller, P. Loskill, M. Cipriano
Training the Next Generation of Researchers in the Organ-on-Chip Field
Educ. Sci, 2023, 13, 144, https://doi.org/10.3390/educsci13020144
C. Mummery, P. Loskill
Go with the flow: Human tissue models beyond cells alone
Stem Cell Rep., 2021, 16, 2029-2032, https://doi.org/10.1016/j.stemcr.2021.08.013
P. Loskill, R. Hardwick, A. Roth
Challenging the pipeline
Stem Cell Rep., 2021, 16, 2033-2037, https://doi.org/10.1016/j.stemcr.2021.08.004
L.L. Sohn, P. Schwille, A. Hierlemann, S. Tay, J. Samitier, J. Fu, P. Loskill
How Can Microfluidic and Microfabrication Approaches Make Experiments More Physiologically Relevant?
Cell Syst., 2020, 11, 209-211, https://doi.org/10.1016/j.cels.2020.07.003
J. Rogal, M. Cipriano, P. Loskill
Organ-on-Chip: Playing LEGO® with mini-organs to reduce animal testing and make medicines safer
Front Young Minds, 2020, 8, 544390, https://doi.org/10.3389/frym.2020.544390
U. Marx, T. Akabane, T.B. Andersson, E. Baker, M. Beilmann, S. Beken, S. Brendler-Schwaab, M. Cirit, R. David, E.-M. Dehne, I. Durieux, L. Ewart, S.C. Fitzpatrick, O. Frey, F. Fuchs, L.G. Griffith, G.A. Hamilton, T. Hartung, J. Hoeng, H. Hogberg, D.J. Hughes, D.E. Ingber, A. Iskandar, T. Kanamori, H. Kojima, J. Kuehnl, M. Leist, B. Li, P. Loskill, D.L. Mendrick, T. Neumann, G. Pallocca, I. Rusyn, L. Smirnova, T. Steger-Hartmann, D.A. Tagle, A. Tonevitsky, S. Tsyb, M. Trapecar, B. van de Water, J. van den Eijnden-van Raaij, P. Vulto, K. Watanabe, A. Wolf, X. Zhou, A. Roth
Biology-inspired microphysiological systems to advance patient benefit and animal welfare in drug development
ALTEX, 2020, 37, 364-394, https://doi.org/10.14573/altex.2001241
M. Mastrangeli, S. Millet, C. Mummery, P. Loskill, D. Braeken, W. Eberle, M. Cipriano, L. Fernandez, M. Graef, X. Gidrol, N. Picollet-D’Hahan, B. van Meer, I. Ochoa, M. Schutte, J. van den Eijnden-van Raaij
Organ-on-chip in development: Towards a roadmap for organs-on-chip
ALTEX, 2019, 36, 650-668, https://doi.org/10.14573/altex.1908271
N. Franzen, W. van Harten, V. Retel, P. Loskill, A.J.M van den Eijnden-van-Raaij, M. IJzerman
Impact of organ-on-a-chip technology on pharmaceutical R&D costs
Drug Discov. Today, 2019, 24, 1720-1724, https://doi.org/10.1016/j.drudis.2019.06.003
M. Mastrangeli, S. Millet, C. Mummery, P. Loskill, D. Braeken, W. Eberle, M. Cipriano, L. Fernandez, M. Graef, X. Gidrol, N. Picollet-D’Hahan, B. van Meer, I. Ochoa, M. Schutte, J. van den Eijnden-van Raaij
Building blocks for a European Organ-on-Chip roadmap
ALTEX, 2019, 36, 481-492 , https://doi.org/10.14573/altex.1905221
P. Loskill, J. Wu
Stem cell based human organ-on-a-chip models for drug discovery and development
Adv. Drug. Deliv. Rev., 2019, 140, 1-2, https://doi.org/10.1016/j.addr.2019.07.004
P. Loskill, N. Huebsch
Engineering Tissues from Induced Pluripotent Stem Cells
Tissue Eng., 2019, 25, 707-710, https://doi.org/10.1089/ten.TEA.2019.0118
C. Probst, S. Schneider, P. Loskill
High-throughput organ-on-a-chip systems: Current status and remaining challenges
Cur. Opin. Biomed. Eng., 2018, 6, 33-41, https://doi.org/10.1016/j.cobme.2018.02.004
J. Nawroth*, J. Rogal*, M. Weiss, S.Y. Brucker, P. Loskill
Organ-on-a-chip Systems for Women’s Health
Adv. Healthc. Mater., 2018, 7, 1700550, http://www.dx.doi.org/10.1002/adhm.201700550
