Dr. Madalena Cipriano

Senior Scientist

Madalena graduated with a PharmD in the Universidade de Lisboa. She started to work in the Chemical Biology and Toxicology Group of the Research Institute for Medicines and Pharmaceutical Sciences (iMed.ULisboa) as an undergraduate student, studying redox regulation and using 3D breast cancer cell models for drug screening studies. During her Ph.D., Madalena developed stem cell derived long-term hepatic models using several 3D cell culture systems. During this time, she was a visiting researcher in the Bioreactor Group, Berlin Brandenburg Center for Regenerative Therapies (BCRT), Charité Universitätsmedizin Berlin. Madalena obtained her Ph.D. in Pharmacy (Toxicology) from the Universidade de Lisboa in 2017.

In 2018, Madalena worked in the European Union Reference Laboratory for alternatives to animal testing (EURL-ECVAM) supporting the input of the European Commission to the development of international guidance on the use of in vitro methods for classification and labelling of chemicals (GHS) and gaining a broad knowledge of regulatory toxicology, test method validation and applications of alternative methods in biomedical research. Madalena joined the Organ-on-a-Chip group as a postdoctoral fellow in July 2018.

Madalena’s current research covers the application of OoC to the pharmaceutical research and the development using the Retina on Chip and the immunocompetent model of the choroid of the eye (Choroid on Chip). Madalena is also involved on activities within the ORCHID project on the training needs of the next generation of scientists and technicians in the Organ-on-a-chip field. Madalena was awarded with a Marie Curie IF in 2018 and will soon start work on a 2-organ-on-chip to study the metabolic interaction between the liver and the white adipose tissue in the context of metabolic syndrome and NAFLD.

Publications

J. Rogal, J. Roosz, C. Teufel, M. Cipriano, R. Xu, W. Eisler, M. Weiss, K. Schenke-Layland, P. Loskill
Autologous human immunocompetent white adipose tissue-on-chip
Adv. Sci., 2022, 2104451, https://doi.org/10.1002/advs.202104451

T. Shroff*, K. Aina*, C. Maass, M. Cipriano, J. Lambrecht, F. Tacke, A. Mosig, P. Loskill
Studying metabolism with multi-organ chips: new tools for disease modelling, pharmacokinetics and pharmacodynamics
Open Biol, 2022, 12, 210333, https://doi.org/10.1098/rsob.210333

L. Mesch, N. Pashkovskaia, V. Cora, S. Pars, S. Corti, M. Cipriano, P. Loskill, E. Koertvely, S. Kustermann, M. Mesquida, A. Kleger, S. Liebau, K. Achberger
Aged human iPSC-RPE organoid cultures display hallmarks of drusen formation
BioRxiv, 2022, under review, https://doi.org/10.1101/2021.10.12.463899

M. Cipriano, K. Schlünder, C. Probst, K. Linke, M. Weiss, M.J. Fischer, L. Mesch, K. Achberger, S. Liebau, M. Mesquida, V. Nicolini, A. Schneider, A.M. Giusti, S. Kustermann, P. Loskill
Human immunocompetent choroid-on-chip: a novel tool for studying ocular effects of biological drugs
Commun. Biol., 2022, 5, 52, https://doi.org/10.1038/s42003-021-02977-3

K. Achberger*, M. Cipriano*, M. Düchs*, C. Schön*, S. Michelfelder, B. Stierstorfer, T. Lamla, S.G. Kauschke, J. Chuchuy, J. Roosz, L. Mesch, V. Cora, S. Pars, N. Pashkovskaia, S. Corti, S.-M. Hartmann, A. Kleger, S. Kreuz, U. Maier, S. Liebau, P. Loskill
Human stem cell-based retina-on-chip as new translational model for validation of AAV retinal gene therapy vectors
Stem Cell Rep., 2021, 16, 2242-2256, https://doi.org/10.1016/j.stemcr.2021.08.008

I.T. Maulana, E. Kromidas, L. Wallstabe, M. Cipriano, M. Alb, C. Zaupa, M. Hudescek, B. Fogal, P. Loskill
Immunocompetent cancer-on-chip models to assess immuno-oncology therapy
Adv. Drug. Deliv. Rev., 2021, 173, 281-305, https://doi.org/10.1016/j.addr.2021.03.015

J. Rogal, M. Cipriano, P. Loskill
Organ-on-Chip: Playing LEGO® with mini-organs to reduce animal testing and make medicines safer
Front Young Minds, 2020, 8, 544390, https://doi.org/10.3389/frym.2020.544390

M. Mastrangeli, S. Millet, C. Mummery, P. Loskill, D. Braeken, W. Eberle, M. Cipriano, L. Fernandez, M. Graef, X. Gidrol, N. Picollet-D’Hahan, B. van Meer, I. Ochoa, M. Schutte, J. van den Eijnden-van Raaij
Organ-on-chip in development: Towards a roadmap for organs-on-chip
ALTEX, 2019, 36, 650-668, https://doi.org/10.14573/altex.1908271

M. Mastrangeli, S. Millet, C. Mummery, P. Loskill, D. Braeken, W. Eberle, M. Cipriano, L. Fernandez, M. Graef, X. Gidrol, N. Picollet-D’Hahan, B. van Meer, I. Ochoa, M. Schutte, J. van den Eijnden-van Raaij
Building blocks for a European Organ-on-Chip roadmap
ALTEX, 2019, 36, 481-492 , https://doi.org/10.14573/altex.1905221