Dr. Madalena Cipriano
Senior Scientist
Madalena earned her PharmD from the Universidade de Lisboa, where she later completed a Ph.D. in Pharmacy (Toxicology) in 2017. Her doctoral research focused on developing 3D hepatic models for drug toxicology. During this time, she was a visiting researcher with the Bioreactor Group at the Berlin Brandenburg Center for Regenerative Therapies (BCRT), Charité Universitätsmedizin Berlin.
Following her Ph.D., Madalena worked at the European Union Reference Laboratory for Alternatives to Animal Testing (EURL-ECVAM), where she supported the European Commission in developing international guidance on using in vitro methods for chemical classification and labelling (GHS).
In July 2018, she joined the Organ-on-a-Chip (OoC) group as a postdoctoral fellow at the Fraunhofer Institute. There, Madalena’s research focused on applying OoC technology to pharmaceutical research and development, with a particular emphasis on ocular models such as the retina-Chip and immunocompetent choroid-Chip. She used these models to evaluate drug delivery, efficacy, or safety of novel chemical entities (NCEs), including bi-specific antibodies (TCBs), AAVs, and antisense oligonucleotides (ASOs). Later, Madalena was awarded a Marie Curie Individual Fellowship, enabling her to work on the liver-white adipose tissue model for studying metabolic interactions in metabolic syndrome and non-alcoholic fatty liver disease (NAFLD).During this time Madalena was also involved in aspects of organ-on-chip development, training and 3Rs initiatives, particularly by participating in the ORCHID consortium,
Currently, Madalena oversees metabolism-related projects at µOrganoLab. Her work focuses on developing our models and new features towards the specific needs of drug testing, insulin production, and metabolic responses, implementing advance sensing approaches on the white adipose tissue-chip, liver-chip, heart-chip and pancreas-chip, as well as 2-organ combinations thereof, to drive advancements in therapeutic research.
Publications
J. Rogal, J. Roosz, C. Teufel, M. Cipriano, R. Xu, W. Eisler, M. Weiss, K. Schenke-Layland, P. Loskill
Autologous human immunocompetent white adipose tissue-on-chip
Adv. Sci., 2022, 2104451, https://doi.org/10.1002/advs.202104451
T. Shroff*, K. Aina*, C. Maass, M. Cipriano, J. Lambrecht, F. Tacke, A. Mosig, P. Loskill
Studying metabolism with multi-organ chips: new tools for disease modelling, pharmacokinetics and pharmacodynamics
Open Biol, 2022, 12, 210333, https://doi.org/10.1098/rsob.210333
M. Cipriano, K. Schlünder, C. Probst, K. Linke, M. Weiss, M.J. Fischer, L. Mesch, K. Achberger, S. Liebau, M. Mesquida, V. Nicolini, A. Schneider, A.M. Giusti, S. Kustermann, P. Loskill
Human immunocompetent choroid-on-chip: a novel tool for studying ocular effects of biological drugs
Commun. Biol., 2022, 5, 52, https://doi.org/10.1038/s42003-021-02977-3
A. Moruzzi, T. Shroff, S. Keller, P. Loskill, M. Cipriano
Training the Next Generation of Researchers in the Organ-on-Chip Field
Educ. Sci, 2023, 13, 144, https://doi.org/10.3390/educsci13020144
Miriam Alb, Kristin Reiche, Michael Rade, Katherina Sewald, Peter Loskill, Madalena Cipriano, Tengku Ibrahim Maulana, Andries D. van der Meer, Huub J. Weener, Laure-Alix Clerbaux, Birgit Fogal, Nirav Patel, Karissa Adkins, Emma Lund, Ethan Perkins, Christopher Cooper, Jan van den Brulle, Hannah Morgan, Tina Rubic-Schneider, Hui Ling, Keith DiPetrillo, Jonathan Moggs, Ulrike Köhl, Michael Hudecek
Novel strategies to assess cytokine release mediated by chimeric antigen receptor T cells based on the adverse outcome pathway concept
J. Immunotoxicol., 2024, 21, S13–S28, https://doi.org/10.1080/1547691X.2024.2345158
K. Schlünder, M. Cipriano, A. Zbinden, S. Fuchs, T. Mayr, K. Schenke-Layland, P. Loskill
Microphysiological Pancreas-on-Chip Platform with Integrated Sensors to Model Endocrine Function and Metabolism
Lab Chip, 2024, 24, 2080-2093, https://doi.org/10.1039/D3LC00838J
T.I. Maulana, C. Teufel, M. Cipriano, J. Roosz, L. Lazarevski, F.E. van den Hil, L. Scheller, V. Orlova, A. Koch, M. Hudecek, M. Alb, P. Loskill
Breast cancer-on-chip for patient-specific efficacy and safety testing of CAR-T cells
Cell Stem Cell, 2024, 31, 989-1002, https://doi.org/10.1016/j.stem.2024.04.018
K. Achberger*, M. Cipriano*, M. Düchs*, C. Schön*, S. Michelfelder, B. Stierstorfer, T. Lamla, S.G. Kauschke, J. Chuchuy, J. Roosz, L. Mesch, V. Cora, S. Pars, N. Pashkovskaia, S. Corti, S.-M. Hartmann, A. Kleger, S. Kreuz, U. Maier, S. Liebau, P. Loskill
Human stem cell-based retina-on-chip as new translational model for validation of AAV retinal gene therapy vectors
Stem Cell Rep., 2021, 16, 2242-2256, https://doi.org/10.1016/j.stemcr.2021.08.008
I.T. Maulana, E. Kromidas, L. Wallstabe, M. Cipriano, M. Alb, C. Zaupa, M. Hudescek, B. Fogal, P. Loskill
Immunocompetent cancer-on-chip models to assess immuno-oncology therapy
Adv. Drug. Deliv. Rev., 2021, 173, 281-305, https://doi.org/10.1016/j.addr.2021.03.015
J. Rogal, M. Cipriano, P. Loskill
Organ-on-Chip: Playing LEGO® with mini-organs to reduce animal testing and make medicines safer
Front Young Minds, 2020, 8, 544390, https://doi.org/10.3389/frym.2020.544390
M. Mastrangeli, S. Millet, C. Mummery, P. Loskill, D. Braeken, W. Eberle, M. Cipriano, L. Fernandez, M. Graef, X. Gidrol, N. Picollet-D’Hahan, B. van Meer, I. Ochoa, M. Schutte, J. van den Eijnden-van Raaij
Organ-on-chip in development: Towards a roadmap for organs-on-chip
ALTEX, 2019, 36, 650-668, https://doi.org/10.14573/altex.1908271
M. Mastrangeli, S. Millet, C. Mummery, P. Loskill, D. Braeken, W. Eberle, M. Cipriano, L. Fernandez, M. Graef, X. Gidrol, N. Picollet-D’Hahan, B. van Meer, I. Ochoa, M. Schutte, J. van den Eijnden-van Raaij
Building blocks for a European Organ-on-Chip roadmap
ALTEX, 2019, 36, 481-492 , https://doi.org/10.14573/altex.1905221