Prof. Dr. Peter Loskill


Prof. Dr. Peter Loskill is W3-Professor for Organ-on-Chip-Research at the Eberhard Karls University Tübingen and the Natural and Medical Sciences Institute (NMI) as well as Vice-Chair of the European-Organ-on-Chip-Society (EUROoCS). He graduated in 2012 from Saarland University with a PhD in Physics and thereafter worked as a postdoctoral fellow at UC Berkeley. In 2015, he was named as one of Technology Review’s “Innovators under 35 Germany” and awarded a Fraunhofer ATTRACT starting grant. He now heads the µOrgano-Lab and the 3R Center Tübingen for In vitro Models and Alternatives to Animal Testing. The interdisciplinary µOrgano-Lab combines approaches from engineering, biology, physics and medicine to generate and apply novel microphysiological tissue models recapitulating complex human biology in vitro. The 3R Center Tübingen aims to provide all scientists in Baden-Württemberg with low-threshold access to novel alternative methods to animal testing.


J. Rogal*, K. Schlünder*, P. Loskill
Developer’s Guide to an Organ-on-Chip Model
ACS Biomater. Sci. Eng., 2022, 8, 4643-4647,

O. Schneider, A. Moruzzi, S. Fuchs, A. Grobel, H.S. Schulze, T. Mayr, P. Loskill
Fusing spheroids to aligned μ-tissues in a heart-on-chip featuring oxygen sensing and electrical pacing capabilities
Mater. Today Bio, 2022, 15, 100280,

J. Rogal, J. Roosz, C. Teufel, M. Cipriano, R. Xu, W. Eisler, M. Weiss, K. Schenke-Layland, P. Loskill
Autologous human immunocompetent white adipose tissue-on-chip
Adv. Sci., 2022, 2104451,

U. Arslan*, A. Moruzzi*, J. Nowacka*, C. Mummery°, D. Eckardt°, P. Loskill°, V. Orlova°
Microphysiological stem cell models of the human heart
Mater. Today Bio, 2022, 14, 100259,

J. Marzi, M. B. Stope, M. Henes, A. Koch, T. Wenzel, M. Holl, S. L. Layland, F. Neis, H. Bösmüller, F. Ruoff, M. Templin, B. Krämer, A. Staebler, J. Barz, D. A. Carvajal Berrio, M. Enderle, P. Loskill, S. Y. Brucker, K. Schenke-Layland, M. Weiss
Non-invasive Physical Plasma (NIPP) as Innovative and Tissue-preserving Therapy for Women Positive for Cervical intraepithelial Neoplasia
Cancers, 2022, 14, 1933,

T. Shroff*, K. Aina*, C. Maass, M. Cipriano, J. Lambrecht, F. Tacke, A. Mosig, P. Loskill
Studying metabolism with multi-organ chips: new tools for disease modelling, pharmacokinetics and pharmacodynamics
Open Biol, 2022, 12, 210333,

K. Stadelmann, A. Weghofer, M. Urbanczyk, I.T. Maulana, P. Loskill, P.D. Jones, K. Schenke-Layland
Development of a bi-layered cryogenic electrospun polylactic acid scaffold to study calcific aortic valve disease in a 3D co-culture model
Acta Biomater., 2022, 140, 364-378,

J. Rogal*, J. Roosz*, P. Loskill
Isolation, Integration, and Culture of Human Mature Adipocytes Leveraging Organ-on-Chip Technology
In: Rasponi M. (eds) Organ-on-a-Chip. Methods in Molecular Biology, vol 2373. Humana, New York, NY., 2022,

M. Cipriano, K. Schlünder, C. Probst, K. Linke, M. Weiss, M.J. Fischer, L. Mesch, K. Achberger, S. Liebau, M. Mesquida, V. Nicolini, A. Schneider, A.M. Giusti, S. Kustermann, P. Loskill
Human immunocompetent choroid-on-chip: a novel tool for studying ocular effects of biological drugs
Commun. Biol., 2022, 5, 52,

T.I. Maulana, C. Teufel, M. Cipriano, L. Lazarevski, F.E. van den Hil, V. Orlova, A. Koch, M. Alb, M. Hudecek, P. Loskill
Solid tumor-on-chip model for efficacy and safety assessment of CAR-T cell therapy
BioRxiv, 2023, Under review,

S.I. Dreher, P. Grubba, C. von Toerne, A. Moruzzi, J. Maurer, T. Goj, A.L. Birkenfeld, A. Peter, P. Loskill, S. Hauck, C. Weigert
Engineering of human myotubes toward a mature metabolic and contractile phenotype
BioRxiv, 2023, under review,

S. Costa, V. Vilas-Boas, F. Lebre, J.M. Granjeiro, C.M. Catarino, L. Moreira Teixeira, P. Loskill, E. Alfaro-Moreno, A.R. Ribeiro
Microfluidic-based skin-on-chip systems for safety assessment of nanomaterials
Trends in Biotechnology, 2023, in press,

L. Mesch, N. Pashkovskaia, V. Cora, S. Pars, S. Corti, M. Cipriano, P. Loskill, E. Koertvely, S. Kustermann, M. Mesquida, A. Kleger, S. Liebau, K. Achberger
Aged human iPSC-RPE organoid cultures display hallmarks of drusen formation
BioRxiv, 2023, under review,

A. Moruzzi, T. Shroff, S. Keller, P. Loskill, M. Cipriano
Training the Next Generation of Researchers in the Organ-on-Chip Field
Educ. Sci, 2023, 13, 144,

C. Mummery, P. Loskill
Go with the flow: Human tissue models beyond cells alone
Stem Cell Rep., 2021, 16, 2029-2032,

S. Schneider, M. Bubeck, J. Rogal, H. Weener, C. Rojas, M. Weiss, M. Heymann, A.D. van der Meer, P. Loskill
Peristaltic on-chip pump for tunable media circulation and whole blood perfusion in PDMS-free organ-on-chip and Organ-Disc systems
Lab Chip, 2021, 21, 3963-3978,

P. Loskill, R. Hardwick, A. Roth
Challenging the pipeline
Stem Cell Rep., 2021, 16, 2033-2037,

K. Achberger*, M. Cipriano*, M. Düchs*, C. Schön*, S. Michelfelder, B. Stierstorfer, T. Lamla, S.G. Kauschke, J. Chuchuy, J. Roosz, L. Mesch, V. Cora, S. Pars, N. Pashkovskaia, S. Corti, S.-M. Hartmann, A. Kleger, S. Kreuz, U. Maier, S. Liebau, P. Loskill
Human stem cell-based retina-on-chip as new translational model for validation of AAV retinal gene therapy vectors
Stem Cell Rep., 2021, 16, 2242-2256,

M. Radisic, P. Loskill
Beyond PDMS and Membranes: New Materials for Organ-on-a-Chip Devices
ACS Biomater. Sci. Eng., 2021, 7, 2861-2863,

S. Schneider*, E. Bras*, O. Schneider, K.U. Schlünder, P. Loskill
Facile Patterning of Thermoplastic Elastomers and Robust Bonding to Glass and Thermoplastics for Microfluidic Cell Culture and Organ-on-Chip
Micromachines, 2021, 12, 575,

S. Schneider, D. Diesing, A. Richter, P. Loskill
Membrane integration into PDMS-free microfluidic platforms for organ-on-chip and analytical chemistry applications
Lab Chip, 2021, 21, 1866-1885,

I.T. Maulana, E. Kromidas, L. Wallstabe, M. Cipriano, M. Alb, C. Zaupa, M. Hudescek, B. Fogal, P. Loskill
Immunocompetent cancer-on-chip models to assess immuno-oncology therapy
Adv. Drug. Deliv. Rev., 2021, 173, 281-305,

F. Hornung, J. Rogal, P. Loskill, B. Löffler, S. Deinhardt-Emmer
The Inflammatory Profile of Obesity and the Role on Pulmonary Bacterial and Viral Infections
Int. J. Mol. Sci., 2021, 22, 3456,

J. Chuchuy, J. Rogal, T. Ngo, K. Stadelmann, L. Antkowiak, K. Achberger, S. Liebau, K. Schenke-Layland, P. Loskill
Integration of Electrospun Membranes into Low-Absorption Thermoplastic Organ-on-Chip
ACS Biomater. Sci. Eng., 2021, 7, 3006-3017,

A. Zbinden, M. Urbanczyk, S. Schenke-Layland, L. Becker, J. Marzi, M. Bosch, P. Loskill, G.P. Duffy, K. Schenke-Layland
Collagen and endothelial cell co-culture improves β-cell functionality and rescues pancreatic ECM
Tissue Eng., 2021, 27, 977-991,

L.L. Sohn, P. Schwille, A. Hierlemann, S. Tay, J. Samitier, J. Fu, P. Loskill
How Can Microfluidic and Microfabrication Approaches Make Experiments More Physiologically Relevant?
Cell Syst., 2020, 11, 209-211,

J. Rogal, M. Cipriano, P. Loskill
Organ-on-Chip: Playing LEGO® with mini-organs to reduce animal testing and make medicines safer
Front Young Minds, 2020, 8, 544390,

A. Zbinden, D.A. Carvajal Berrio, M. Urbanczyk, S. Schenke-Layland, M. Bosch, S. Fliri, C.-en Lu, A. Jeyagaran, P. Loskill, G.P. Duffy, K. Schenke-Layland
Non-invasive metabolic mapping of hypoxia-induced damage in a pancreas-on-chip system
J. Biophotonics, 2020, 13, e202000375,

S. Schneider, F. Erdemann, O. Schneider, T. Hutschalik, P. Loskill
Organ-on-a-Disc — A platform technology for the centrifugal generation and culture of microphysiological 3D cell constructs amenable for automation and parallelization
APL Bioengineering, 2020, 4, 046101,

W.M. Reese, P. Burch, A.B. Korpusik, S.E. Liu, P. Loskill, P.B. Messersmith, K.E. Healy
Facile Macrocyclic Polyphenol Barrier Coatings for PDMS Microfluidic Devices
Adv. Funct. Mater., 2020, 2001274,

U. Marx, T. Akabane, T.B. Andersson, E. Baker, M. Beilmann, S. Beken, S. Brendler-Schwaab, M. Cirit, R. David, E.-M. Dehne, I. Durieux, L. Ewart, S.C. Fitzpatrick, O. Frey, F. Fuchs, L.G. Griffith, G.A. Hamilton, T. Hartung, J. Hoeng, H. Hogberg, D.J. Hughes, D.E. Ingber, A. Iskandar, T. Kanamori, H. Kojima, J. Kuehnl, M. Leist, B. Li, P. Loskill, D.L. Mendrick, T. Neumann, G. Pallocca, I. Rusyn, L. Smirnova, T. Steger-Hartmann, D.A. Tagle, A. Tonevitsky, S. Tsyb, M. Trapecar, B. van de Water, J. van den Eijnden-van Raaij, P. Vulto, K. Watanabe, A. Wolf, X. Zhou, A. Roth
Biology-inspired microphysiological systems to advance patient benefit and animal welfare in drug development
ALTEX, 2020, 37, 364-394,

J. Rogal, C. Binder, E. Kromidas, J. Roosz, C. Probst, S. Schneider, K. Schenke-Layland, P. Loskill
WAT-on-a-chip integrating human mature white adipocytes for mechanistic research and pharmaceutical applications
Sci. Rep., 2020, 10, 6666,

A. Zbinden, J. Marzi, K. Schlünder, C. Probst, M. Urbanczyk, S. Black, E. Brauchle, S.L. Layland, U. Kraushaar, G. Duffy, K. Schenke-Layland, P. Loskill
Non-invasive marker-independent high content analysis of a microphysiological human pancreas-on- a-chip model
Matrix Biol, 2020, 85-86, 205-220,

M. Mastrangeli, S. Millet, C. Mummery, P. Loskill, D. Braeken, W. Eberle, M. Cipriano, L. Fernandez, M. Graef, X. Gidrol, N. Picollet-D’Hahan, B. van Meer, I. Ochoa, M. Schutte, J. van den Eijnden-van Raaij
Organ-on-chip in development: Towards a roadmap for organs-on-chip
ALTEX, 2019, 36, 650-668,

K. Achberger*, C. Probst*, J.C. Haderspeck*, S. Bolz, J. Rogal, J. Chuchuy, M. Nikolova, V. Cora, L. Antkowiak, W. Haq, N. Shen, K. Schenke-Layland, M. Ueffing, S. Liebau, P. Loskill
Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human Retina-on-a-Chip platform
eLife, 2019, 8, e46188,

N. Franzen, W. van Harten, V. Retel, P. Loskill, A.J.M van den Eijnden-van-Raaij, M. IJzerman
Impact of organ-on-a-chip technology on pharmaceutical R&D costs
Drug Discov. Today, 2019, 24, 1720-1724,

M. Mastrangeli, S. Millet, C. Mummery, P. Loskill, D. Braeken, W. Eberle, M. Cipriano, L. Fernandez, M. Graef, X. Gidrol, N. Picollet-D’Hahan, B. van Meer, I. Ochoa, M. Schutte, J. van den Eijnden-van Raaij
Building blocks for a European Organ-on-Chip roadmap
ALTEX, 2019, 36, 481-492 ,

P. Loskill, J. Wu
Stem cell based human organ-on-a-chip models for drug discovery and development
Adv. Drug. Deliv. Rev., 2019, 140, 1-2,

J. Rogal*, A. Zbinden*, K. Schenke-Layland, P. Loskill
Stem-cell based organ-on-a-chip models for diabetes research
Adv. Drug. Deliv. Rev., 2019, 140, 101-128,

M. Weiss, J. Barz, M. Ackermann, R. Utz, A. Ghoul, K.-D. Weltmann, M.B. Stope, D. Wallwiener, K. Schenke-Layland, C. Oehr, S. Brucker, P. Loskill
Dose-dependent Tissue-Level Characterization of a Medical Atmospheric Pressure Argon Plasma Jet
ACS Appl. Mater. Interfaces, 2019, 11, 19841-19853,

P. Loskill, N. Huebsch
Engineering Tissues from Induced Pluripotent Stem Cells
Tissue Eng., 2019, 25, 707-710,

O. Schneider, L. Zeifang, S. Fuchs, C. Sailer, P. Loskill
User-friendly and paralleled generation of hiPSC-derived μ-tissues in a centrifugal heart-on-a-chip
Tissue Eng., 2019, 25, 786-798,

J.C. Haderspeck*, J. Chuchuy*, S. Kustermann, S. Liebau, P. Loskill
Organ-on-a-Chip technologies that can transform ophthalmic drug discovery and disease modelling
Expert Opin. Drug Discov., 2019, 14, 47-57,

A. Ryan, C. Kearney, N. Shen, U. Khan, A. Kelly, C. Probst, E. Brauchle, S. Biccai, C. Garciarena, V. Vega-Mayoral, P. Loskill, S. Kerrigan, D. Kelly, K. Schenke-Layland, J. Coleman, F. J. O’Brien
Electroconductive Biohybrid Collagen/Pristine Graphene Composite Biomaterials with Enhanced Biological Activity
Adv. Mater., 2018, 30, 1706442,

C. Probst, S. Schneider, P. Loskill
High-throughput organ-on-a-chip systems: Current status and remaining challenges
Cur. Opin. Biomed. Eng., 2018, 6, 33-41,

J. Nawroth*, J. Rogal*, M. Weiss, S.Y. Brucker, P. Loskill
Organ-on-a-chip Systems for Women’s Health
Adv. Healthc. Mater., 2018, 7, 1700550,

P. Loskill, T. Sezhian, K.M. Tharp, F.T. Lee-Montiel, S. Jeeawoody, W.M. Reese, P.-J.H. Zushin, A. Stahl, K.E. Healy
WAT-on-a-chip: a physiologically relevant microfluidic system incorporating white adipose tissue
Lab Chip, 2017, 17, 1645-1654,

J. Rogal, C. Probst, P. Loskill
Integration concepts of Multi-Organ-Chips: How to keep your flexibility?!
Future Science OA, 2017, FSO180,

N. Huebsch, P. Loskill, N. Deveshwar, C.I. Spencer, L. Judge, M.A. Mandegar, C. Fox, T. Mohammed, Z. Ma, A. Mathur, A.S. Sheehan, A. Truong, M. Saxton, J. Yoo, D. Srivastava, T.A. Desai, P.-L. So, K.E. Healy, B. R. Conklin
Miniaturized iPS-Cell-Derived Cardiac Muscles for Physiologically Relevant Drug Response Analyses
Sci. Rep., 2016, 6, 24726,

E. Altiok, J. Santiago, F.L. Svedlund, A. Zbinden, A.K. Jha, D. Bhatnagar, P. Loskill, W. Jackson, D. Schaffer, K.E. Healy
Multivalent Hyaluronic Acid Bioconjugates Improve sFlt-1 Activity In Vitro
Biomaterials, 2016, 93, 95-105,

A. Mathur, Z. Ma, P. Loskill, S. Jeeawoody, K.E. Healy
In Vitro Cardiac Tissue Models: Current Status and Future Prospects
Adv. Drug. Deliv. Rev., 2016, 96, 203-213,

N. Thewes, P. Loskill, C. Spengler, S. Hümbert, M. Bischoff, K. Jacobs
A detailed guideline for the fabrication of single bacterial probes used for atomic force spectroscopy
Eur. Phys. J. E, 2015, 38, 140,

P. Loskill, S.G. Marcus, A. Mathur, W.M. Reese, K.E. Healy
μOrgano: A Lego-Like Plug & Play System for Modular Multi-Organ-Chips
PLOS ONE, 2015, 10, e0139587,

N. Thewes, A. Thewes, P. Loskill, H. Peisker, M. Bischoff, M. Herrmann, L. Santen, K. Jacobs
Initiation of contact during the adhesion of S. aureus studied by atomic force spectroscopy and Monte Carlo simulations
Soft Matter, 2015, 11, 8913-8919,

H. Jeon, S. Koo, W.M. Reese, P. Loskill, C.P. Grigoropoulos, K.E. Healy
Directing cell migration and organization via nanocrater-patterned cell-repellent interfaces
Nat. Mater., 2015, 14, 918–923,

Z. Ma, J. Wang, P. Loskill, N. Huebsch, S. Koo, F.L. Svedlund, N.C. Marks, E.W. Hua, C.P. Grigoropoulos, B.R. Conklin, K. E. Healy
Self-organizing human cardiac microchambers mediated by geometric confinement
Nat. Commun., 2015, 6, 7413,

A. Mathur, P. Loskill, K. Shao, N. Huebsch, S. Hong, S.G. Marcus, N. Marks, L.P. Lee, B. Conklin, K.E. Healy
Human iPSC-based Cardiac Microphysiological System For Drug Screening Applications
Sci. Rep., 2015, 5, 8883,

N. Huebsch*, P. Loskill*, M.A. Mandegar, N. Marks, A.S. Sheehan, Z. Ma, A. Mathur, T.N. Nguyen, J. Yoo, L. Judge, C. Spencer, A. Chukka, C. Russell, P.L. So, B. Conklin, K.E. Healy
Automated Video-Based Analysis of Contractility and Calcium Flux in Human-Induced Pluripotent Stem-Derived Cardiomyocytes Cultured over Different Spatial Scales
Tissue Eng., 2015, 21, 1-13,

P. Loskill*, P. Pereira*, P. Jung, M. Bischoff, M. Herrmann, M. Pinho, K. Jacobs
Reduction of the peptidoglycan crosslinking causes a decrease in stiffness of the Staphylococcus aureus cell envelope
Biophys. J., 2014, 107, 1082-1089,

N. Thewes, P. Loskill, P. Jung, H. Peisker, M. Bischoff, M. Herrmann, K. Jacobs
Hydrophobic interaction governs unspecific adhesion of staphylococci: a single cell force spectroscopy study
Beilstein J. Nanotech., 2014, 5, 1502-1512,

Z. Ma, S. Koo, M.A. Finnegan, P. Loskill, N. Huebsch, N.C. Marks, B.R. Conklin, C.P. Grigoropoulos, K.E. Healy
Three-dimensional filamentous human diseased cardiac tissue model
Biomaterials, 2014, 35, 1367-1377,

A. Mathur, P. Loskill, S. Hong, J.Y. Lee, S.G. Marcus, L. Dumont, B.R. Conklin, H. Willenbring, L.P. Lee, K.E. Healy
Human Induced Pluripotent Stem Cell-Based Microphysiological Tissue Models of Myocardium and Liver for Drug Development
Stem Cell Res. Ther., 2013, 4, (Suppl 1):S14,

M. Lessel, P. Loskill, K. Jacobs, F. Hausen, N.N. Gosvami, R. Bennewitz
Impact of van der Waals interactions on single asperity friction
Phys. Rev. Lett., 2013, 111, 035502,

P. Loskill*, J. Puthoff*, M. Wilkinson, K. Mecke, K. Jacobs, K. Autumn
Macroscale adhesion of gecko setae reflects nanoscale differences in subsurface composition
J. R. Soc. Interface, 2013, 10, 20120587,

P. Loskill, H. Hähl, T. Faidt, S. Grandthyll, F. Müller, K. Jacobs
Is adhesion superficial? Silicon wafers as a model system to study van der Waals interactions
Adv. Colloid Interface Sci., 2012, 179-182, 107-113,

H. Hähl, F. Evers, S. Grandthyll, M. Paulus, C. Sternemann, P. Loskill, M. Lessel, A.K. Hüsecken, T. Brenner, M. Tolan, K. Jacobs
Subsurface influence on the structure of protein adsorbates revealed by in situ X-ray reflectivity
Langmuir, 2012, 28, 7747–7756,