Lab-on-Chip systems (LoC) have been developed and applied in academic research for more than a decade and are now being increasingly used in several industrial applications. Technology transfer from academia to industry, however, is often hindered by the limited manufacturing methods and materials used in academic research and startups. Currently, prototypes of microfluidic systems are most often fabricated of Polydimethylsiloxane (PDMS), a polymer known to adsorb small molecules and with severe limitations for mass production. The aim of this project is to develop a new generation of versatile materials, coatings and fabrication approaches for LoC systems, specifically focusing on the requirements of Organ-on-Chip technology, which merge biocompatibility and scalability.

Publications

M. Radisic, P. Loskill
Beyond PDMS and Membranes: New Materials for Organ-on-a-Chip Devices
ACS Biomater. Sci. Eng., 2021, 7, 2861-2863, https://doi.org/10.1021/acsbiomaterials.1c00831

S. Schneider*, E. Bras*, O. Schneider, K.U. Schlünder, P. Loskill
Facile Patterning of Thermoplastic Elastomers and Robust Bonding to Glass and Thermoplastics for Microfluidic Cell Culture and Organ-on-Chip
Micromachines, 2021, 12, 575, https://doi.org/10.3390/mi12050575

S. Schneider, D. Diesing, A. Richter, P. Loskill
Membrane integration into PDMS-free microfluidic platforms for organ-on-chip and analytical chemistry applications
Lab Chip, 2021, 21, 1866-1885, https://doi.org/10.1039/D1LC00188D

J. Chuchuy, J. Rogal, T. Ngo, K. Stadelmann, L. Antkowiak, K. Achberger, S. Liebau, K. Schenke-Layland, P. Loskill
Integration of Electrospun Membranes into Low-Absorption Thermoplastic Organ-on-Chip
ACS Biomater. Sci. Eng., 2021, 7, 3006-3017, https://doi.org/10.1021/acsbiomaterials.0c01062

W.M. Reese, P. Burch, A.B. Korpusik, S.E. Liu, P. Loskill, P.B. Messersmith, K.E. Healy
Facile Macrocyclic Polyphenol Barrier Coatings for PDMS Microfluidic Devices
Adv. Funct. Mater., 2020, 2001274, https://doi.org/10.1002/adfm.202001274

A. Ryan, C. Kearney, N. Shen, U. Khan, A. Kelly, C. Probst, E. Brauchle, S. Biccai, C. Garciarena, V. Vega-Mayoral, P. Loskill, S. Kerrigan, D. Kelly, K. Schenke-Layland, J. Coleman, F. J. O’Brien
Electroconductive Biohybrid Collagen/Pristine Graphene Composite Biomaterials with Enhanced Biological Activity
Adv. Mater., 2018, 30, 1706442, https://doi.org/10.1002/adma.201706442

C. Probst, S. Schneider, P. Loskill
High-throughput organ-on-a-chip systems: Current status and remaining challenges
Cur. Opin. Biomed. Eng., 2018, 6, 33-41, https://doi.org/10.1016/j.cobme.2018.02.004

J. Rogal, C. Probst, P. Loskill
Integration concepts of Multi-Organ-Chips: How to keep your flexibility?!
Future Science OA, 2017, FSO180, http://www.dx.doi.org/10.4155/fsoa-2016-0092

E. Altiok, J. Santiago, F.L. Svedlund, A. Zbinden, A.K. Jha, D. Bhatnagar, P. Loskill, W. Jackson, D. Schaffer, K.E. Healy
Multivalent Hyaluronic Acid Bioconjugates Improve sFlt-1 Activity In Vitro
Biomaterials, 2016, 93, 95-105, http://www.dx.doi.org/10.1016/j.biomaterials.2016.03.017