Tengku Ibrahim Maulana

PhD Candidate

Ibra studied Medical Engineering at the University of Stuttgart (M. Sc.) and started working in the µOrganoLab on his Master's thesis in 2018. His project focused on the development and integration of patterned hydrogels to establish a novel heart-valve-on-a-chip platform. Afterward, he joined the R&D Department at Emulate Inc. in Boston to perform ECM-microengineering, quantitative analysis, and disease modeling of human hepatic tissue in vitro.

His research interest in cellular microenvironment-modeling and immunotherapy led him to start his Ph.D. in the Loskill-Lab in March 2020, focusing on the development and utilization of patient-derived tumor-on-chip models for safety and efficacy assessment of cancer immunotherapy (e.g. CAR-T cell therapy) and the impact of the tumor microenvironment (e.g. adipose tissue in breast cancer) on tumor growth and treatment response.

Publications

K. Stadelmann, A. Weghofer, M. Urbanczyk, I.T. Maulana, P. Loskill, P.D. Jones, K. Schenke-Layland
Development of a bi-layered cryogenic electrospun polylactic acid scaffold to study calcific aortic valve disease in a 3D co-culture model
Acta Biomater., 2022, 140, 364-378, https://doi.org/10.1016/j.actbio.2021.11.030

T.I. Maulana, C. Teufel, M. Cipriano, L. Lazarevski, F.E. van den Hil, V. Orlova, A. Koch, M. Alb, M. Hudecek, P. Loskill
Solid tumor-on-chip model for efficacy and safety assessment of CAR-T cell therapy
BioRxiv, 2024, Under review, https://doi.org/10.1101/2023.07.13.548856

I.T. Maulana, E. Kromidas, L. Wallstabe, M. Cipriano, M. Alb, C. Zaupa, M. Hudescek, B. Fogal, P. Loskill
Immunocompetent cancer-on-chip models to assess immuno-oncology therapy
Adv. Drug. Deliv. Rev., 2021, 173, 281-305, https://doi.org/10.1016/j.addr.2021.03.015